How long does it typically take to notice significant reduction in radiolucency after finishing a root filling in a tooth with a periapical lesion?

Noticing a significant reduction in radiolucency after completing a root filling in a tooth with a periapical lesion typically takes around six months. This timeframe allows sufficient healing and the natural bone regeneration processes to occur following the completion of endodontic treatment. After root canal therapy, the body begins repairing the affected area, and the changes in the periapical region can be observed radiographically over this period.

While some initial healing might start to occur earlier, substantial and noticeable reduction in the size of the radiolucency generally aligns with the six-month mark due to the time required for bone remodeling and the resolution of any inflammation present. Therefore, this answer accurately reflects the expected timeline in clinical practice.