In patients with Von Willebrand's disease, which factors are affected?

In patients with Von Willebrand's disease, the primary factors that are affected are Factor VIII and the mechanism of platelet adhesion. Von Willebrand factor (vWF) plays a critical role in the process of hemostasis, as it facilitates the adhesion of platelets to the site of vascular injury and stabilizes Factor VIII in circulation. When vWF is deficient or dysfunctional, as is seen in Von Willebrand's disease, both platelet function and the levels of Factor VIII are compromised.

This leads to an increased bleeding tendency, as platelets are unable to effectively adhere to the damaged blood vessel walls, and the stabilized Factor VIII is not available in sufficient amounts to promote normal clotting processes. Therefore, the correct answer highlights the crucial role of both Factor VIII and platelet adhesion in the pathology of Von Willebrand's disease, expressing the key components impacted by this condition that contribute to the bleeding risks in affected patients.