Periodontitis is usually more severe in patients with which of the following?

Periodontitis is an inflammatory disease that affects the supporting structures of the teeth, and its severity can be influenced by the immune response of the individual. Patients with defective neutrophils often exhibit a compromised immune system, which makes it harder for the body to respond effectively to oral pathogens. Neutrophils are essential in the body's first line of defense against infections, including those that can lead to periodontal disease.

When neutrophil function is impaired, the body cannot control the bacterial biofilms that accumulate on the teeth and gums as effectively. This allows for an increase in inflammation and tissue destruction associated with periodontitis. Advanced forms of periodontitis can manifest, leading to more severe repercussions such as tooth mobility and even tooth loss.

In contrast, individuals with healthy neutrophils typically have a better immune response, which aids in managing bacterial infections in the oral cavity. Good oral hygiene practices and regular dental check-ups also play crucial roles in preventing periodontitis, making the presence of defective neutrophils the primary factor linking the severity of the disease to immune system functionality.