What condition presents with indurated margins and is commonly accompanied by systemic symptoms such as fever?

The condition characterized by indurated margins and commonly associated with systemic symptoms like fever is the chancre of syphilis. A chancre is typically a firm, painless ulcer that appears at the site of infection, which often has defined, raised edges that feel hard to the touch.

Systemic symptoms, such as fever, can accompany the primary stage of syphilis, as this infection enters the body and begins to affect the immune system. The presence of a fever indicates that the body is responding to an infection, aligning with the systemic implications of syphilis.

In contrast, oral herpes generally presents with painful vesicles and localized symptoms rather than indurated margins and systemic signs. Gingivitis is primarily an inflammatory response of the gums with bleeding and swelling but does not typically present with induration or fever. Candidiasis, or oral thrush, may show patches but not indurated margins nor systemic illness like a fever in the same way syphilis does. Therefore, the specific characteristics of a chancre in syphilis including the hard edges and the common systemic symptoms make it the correct answer.