What medication is most commonly used to reverse the effects of morphine coma?

Naloxone is the primary medication used to reverse the effects of a morphine overdose or coma. As an opioid antagonist, it works by competitively binding to the same receptors in the brain that opioids like morphine bind to. When Naloxone is administered, it displaces the opioid from these receptors, effectively reversing respiratory depression, sedation, and hypotension associated with opioid overdose. This rapid action is critical in emergency situations where opioid overdose can lead to potentially life-threatening respiratory failure.

In contrast, while bradykinin is involved in inflammation and can play a role in pain signaling, it does not have antagonistic effects on opioid receptors. Epinephrine is a sympathomimetic that can increase heart rate and blood pressure but is not specific for reversing opioid effects. Amphetamine is a stimulant that affects different neurotransmitter systems and is not effective in reversing opioid overdose. Understanding the specific mechanisms and uses of these medications highlights why Naloxone is the gold standard for treating opioid overdose scenarios.