What type of inflammation is primarily seen in advanced lesions of periodontitis?

In advanced lesions of periodontitis, the type of inflammation that is primarily observed is plasma cell dominated. This refers to the immune response where plasma cells, which are differentiated B cells, produce antibodies against persistent bacterial antigens present in the periodontal tissues.

As periodontitis progresses, there is chronic inflammation characterized by the presence of B cells and plasma cells in the affected area. These plasma cells play a critical role in the body's ability to combat infections and contribute to the immune system's response in maintaining periodontal health. Their presence is indicative of a long-standing immune reaction as the body attempts to control the infection associated with periodontal disease.

Other types of inflammation, such as those predominantly featuring neutrophils or lymphocytes, may be more characteristic of earlier stages of periodontal disease or in acute inflammatory responses. Neutrophils are typically involved in the initial defense against bacteria, while lymphocytes may be more active in chronic inflammatory scenarios; however, it is the plasma cell response that is notably highlighted in the advanced stages of periodontitis.