Which of the following conditions is not typically associated with local oral lesions?

Rubella is typically not associated with local oral lesions. The primary manifestations of rubella are systemic, including a characteristic rash and mild fever. While it can have some oral manifestations, such as transient lymphadenopathy, it does not commonly lead to significant oral lesions like the other conditions listed.

In contrast, measles often presents with koplik spots, which are small white lesions found in the mouth before the rash appears. Syphilis can lead to oral lesions known as mucous membrane pemphigoid or gumma in its tertiary stage. Herpes simplex is well-known for causing recurrent oral lesions, such as cold sores or herpes labialis. These conditions have clear associations with localized oral lesions, unlike rubella, which primarily affects the body rather than producing oral manifestations.